Co-processed excipients with microcrystalline cellulose and mannitol in different ratios were fabricated by different methods and its influence on blend fluidity, friability of the tablet and dissolution characteristics of chloroquine phosphate from direct compressible tablets was studied. The flow properties of the blends were determined by carr’s index and hausner’s ratio. The co-processed excipient contained higher proportion of microcrystalline cellulose imparted low flowability and the blends containing high proportion of mannitol failed to meet friability criteria. Optimized co-processed formulation containing microcrystalline cellulose and mannitol in the ratio 9:1 was found to be more acceptable to formulate chloroquine phosphate tablets. The co-processed excipients were prepared by using granulation technique. The preformulation parameters like flow property and the performance parameters were dependent on the proportion of components present in the co-processing excipient. The co-processed excipient prepared with granulation technique imparted the desired qualities to the tablet.
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